Abstract Atopic dermatitis (AD) is a long-term inflammatory skin condition characterised by recurrent episodes of itching, dryness, redness, irritation, and eczematous skin lesions. Its development involves several interconnected factors, including disruption of the skin barrier, abnormal immune responses, genetic predisposition, environmental influences, and alterations in the skin microbiome. Persistent pruritus can result in frequent scratching, which further weakens the skin…
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ABSTRACT Systemic sclerosis is a chronic autoimmune connective tissue disorder where the skin serves as both a mirror and a marker of internal disease. The tightening, thickening, and hardening of the skin not only reflect the pathological process of excessive collagen deposition but also provide the earliest and most visible clues to diagnosis. Beyond being a protective barrier, the skin…
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