Natural Cure For Crigler Najjar Syndrome Type 1


Crigler Najjar syndrome type 1 is a hereditary disorder that results in hepatic bilirubin conjugation causing severe neonatal unconjugated hyperbilirubinemia due to certain mutations in the gene leading to fatal outcomes for the infant. Due to hyperbilirubinemia there occurs bilirubin encephalopathy or kernicterus that is a severe form of brain damage leading to deafness, hypertonia, lethargy and oculomotor palsy. As this is a rare disorder you might not find all the details explained well at one place, hence this article is for you containing every information regarding the Crigler Najjar syndrome (Type 1) (CNS) along with its Ayurvedic management.



CNS type 1 is an inherited disease in which bilirubin cannot be broken down causing hyperbilirubinemia, which is a toxic condition. Bilirubin is a substance which is produced on breaking down of red blood cells and further converted from unconjugated bilirubin (toxic form) into conjugated bilirubin (non toxic form). People suffering from CNS type 1 have build up of unconjugated bilirubin in their blood leading to a toxic condition called unconjugated hyperbilirubinemia.


As per Ayurveda the main cause of diseases is based on the imbalances of any of three doshas, i.e. Vata, Pitta and Kapha and the constitution of the body (Prakriti) have the main role in it. Doshika predominance remains unchangeable and is responsible for the type of diseases one would develop.


In CNS (Type 1) the reason behind not converting unconjugated bilirubin into conjugated bilirubin is an absence of enzyme that catalyzes the chemical reaction. Bilirubin uridine diphosphate glucuronosyltransferase (bilirubin-UGT) enzyme is the one responsible for removal of bilirubin from the body is found in the liver cells normally but in case of CNS (Type 1) it is absent because of mutation in the gene that provides instruction for its production. It is an autosomal recessive disorder which means mutation is found in both the copies of the gene.


Signs and symptoms may differ from one person to another also not all the symptoms listed below might be found in one person. Signs and symptoms are caused due to damage to brain and nerve tissues.

  • Babies are extremely lethargic and tired
  • Weak muscle tone
  • Arching of babies back
  • Sometimes there are seen episodes of increased muscle tone, i.e. hypertonia
  • Involuntary twisting and squirming movements of the body
  • Deafness or other hearing problem
  • Intellectual disability


Making diagnosis of something like Crigller najjar syndrome (Type 1) can be challenging as it is a rare genetic disorder. Proper physical examinations, case history, and laboratory tests together help a doctor in finding out the disease. Genetic testing is the specific test which helps finally in confirmation of the disease condition.


Conventional treatment of CNS (Type 1) includes 10-12 hours per day sessions of phototherapy to maintain the level of unconjugated bilirubin below the toxic level. Further Orthotopic liver transplant can be considered where grafting of tissue is done. This transplant is considered to be more effective if done before the neurological damage initiates. Bilirubin chelators like cholestyramine and calcium salts can be used.


Ayurveda aims at the management of the disorder naturally by balancing the tridosha and relieving the complaints to certain extent. There are many herbs in nature which can help in rectifying the vitiation of the Vata, Pitta and Kapha dosha.


Planet Ayurveda has been serving the suffering humanity for around two decades now. It is a herbal manufacturing company where all the herbal products are manufactured under the strict supervision of experienced MD Ayurveda doctors following authentic Ayurvedic principles. All the herbal products are free from chemicals, preservatives, additives, dye, colors, yeast, etc. For CNS (Type 1) Planet Ayurveda offers a combination of herbal remedies called Liver care pack.


  1. Echinacea Capsules
  2. Yakrit Plihantak Churna
  3. Phyllanthus Niruri
  4. Liver Detox Capsules

Products Description

1. Echinacea Capsule

Kalmegh or Indian Echinacea (Andrographis paniculata) is a well known herb which has been used to treat liver ailments since ages. Echinacea capsules are prepared using the standardized extract of this herb that helps in maintaining a healthy functioning of the liver and also prevent it from the damage caused due to various drugs and infections.

Dosage– Take 2 capsules twice daily after meals with plain water.

2. Yakrit Plihantak Churna

This herbal churna is a therapeutic medicinal mixture of various amazing herbs like Bhumi amla (Phyllanthus niruri), Punarnava (Boerhavia diffusa), Katuki (Picrorhiza kurroa), Makoy (Solanum indicum) etc. Yakrit Plihantak churna helps in elimination of the bilirubin from the body.

Dosage– Take 1 teaspoon twice daily after meals with plain water.

3. Phyllanthus Niruri

As the name suggests these herbal capsules are prepared from standardized extract of Phyllanthus niruri or Bhumi amla. It helps in restoring the liver’s normal function and also helps in conjugation of the bilirubin so that it can be removed from the body. Phyllanthus niruri capsules enhance the action of the liver.

Dosage– Take 2 capsules twice daily after meals with plain water.

4. Liver Detox Formula

Herbs like Punarnava (Boerhavia diffusa), Kaasni (Cichorium intybus), Makoy (Solanum indicum), Kalmegh (Andrographis paniculata), etc. are used in the formulation of Liver detox formula. Liver detox capsules help to eliminate the toxins from the liver and help in preventing nerve and brain damage to certain extent.

Dosage– Take 2 capsules twice daily after meals with plain water.

Note- Dosage will be different for infants and children.


Crigler najjar syndrome (Type 1) can be lethal if left untreated. With proper treatment a child can have a better prognosis and even they can spend normal life including schooling. Adults who suffer from this disorder can have a near normal lifestyle with regular treatment. In case of any query kindly visit For more queries, you can send your queries to our email id

The following two tabs change content below.
Dr. Vikram Chauhan (MD - Ayurveda) is a Globally Renowned Ayurveda Physician with Expertise of more than 25 Years. He is the CEO & Founder of Planet Ayurveda Private Limited, a leading Ayurveda Brand, Manufacturing, and Export Company with a Chain of Clinics and Branches in the US, Europe, Africa, Southeast Asia, India, and other parts of the World. He is also an Ayurveda Author who has written Books on Ayurveda, translated into Many European Languages. One of his Books is "Ayurveda – God’s Manual for Healing". He is on a Mission to Spread Ayurveda All Over the Planet through all the Possible Mediums. With his Vast Experience in Herbs and their Applied Uses, he is successfully treating Numerous Patients suffering from Various Ailments with the help of the Purest Herbal Supplements, Diet, and Lifestyle, according to the Principles of Ayurveda. For More Details, visit