AYURVEDIC REMEDIES AND NATURAL TREATMENT FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH) is a rare disease. It is more common in infants and children. But it can happen to adults too. Children can get genetic diseases. This is called familial HLH. However, many conditions can cause HLH in adults. This is known as acquired HLH. It can be caused by some of the infections, cancer and autoimmune diseases. If you have HLH, it is an indication that your immune system isn’t working as expected. Some WBC called histiocytes and lymphocytes kill other blood cells. Some abnormal blood cells can form in the spleen and liver. This can make your spleen and liver enlarged. HLH is a dangerous disease. Whenever left untreated, it can prompt death within a space of weeks or months. Now we will discuss causes, their types, symptoms, diagnosis, treatment according to modern science, Ayurvedic overview and herbal remedies formulated by Planet Ayurveda.
INTRODUCTION
Adult hemophagocytic lymphohistiocytosis is a life-threatening or rare disease in immunocompromised adults. It is usually a secondary response to an underlying problem (such as immunosuppression, another disease, or cancer) and should be treated immediately. It is also called hemophagocytosis or hemophagocytic syndrome. This serious disease is caused by the uncontrolled growth of active macrophages and lymphocytes that secrete high levels of cytokines.
CAUSES
There are the following causes of hemophagocytic lymphohistiocytosis:
- Viral infections: most frequently Epstein-Barr infection
- Autoimmune diseases
- Fungal and bacterial infections
- A few sorts of malignant growth, like T-cell lymphoma
- Drugs that smother the immune system
TYPES OF HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS
There are mainly two types of HLH:
- Familial Hemophagocytic Lymphohistiocytosis: It is also called Primary HLH and is caused by a hereditary imperfection in the genes that control how the immune system kills bacteria or other destructive cells in the body. These genes incorporate PRF1, MUNC13-4, STXBP2, and STX11. This type is passed from parents to their children.
- Acquired Hemophagocytic Lymphohistiocytosis: It is also called Secondary HLH. It is a serious condition that can be fatal. Symptoms are sometimes seen in normal people with health conditions such as infections or cancer that can lead to a weakened immune system.
SYMPTOMS
There are the following symptoms related to HLH:
- Skin rash
- Splenomegaly: enlargement of the spleen
- Hepatomegaly: enlargement of the liver
- Fever
- Swollen lymph nodes
- Thrombocytopenia
- Seizures
- Visual disturbances
- Headaches
- Irritability
- Dizziness
- Loss of consciousness
- Coma
- Jaundice
- Coughing
- Difficulty breathing
- Vomiting
- Diarrhoea
DIAGNOSIS
- Bone marrow biopsy
- Low levels of WBC, RBC, and platelets
- High levels of fat in your blood
- Decreased level of fibrinogen
- Signs of infection
- Genetic test
- Elevated level of ferritin
TREATMENT
- Chemotherapy
- Blood transfusion
- Antiviral medication
- Anti-inflammatory
- Antibiotics
- Immunotherapy
- Gamma-blocking antibody
- Allogeneic stem cell transplant
AYURVEDIC OVERVIEW OF HLH
At the point when each of the three doshas—Vata, Pitta, and Kapha—is balanced, the body stays healthy. Ayurveda brings well-being and equilibrium. Ayurveda aims to keep up with and work on general well-being, no matter what your age.
प्रयोजनं चास्य स्वस्थ्यस्य स्वास्थ्यरक्षणमातुरस्य विकारप्रशमनं च ।
This means the purpose of this is to keep up the health of the healthy and relieve the disorders of the sick.
In Ayurveda, we can associate this disease with vitiated Vata, Pitta, and Kapha doshas. All three doshas are interdependent. When vitiation of Kapha dosha occurs, it accumulates in the body and increases Pitta dosha. Kapha and Pitta Doshas are affected as well as Vata doshas, causing pain in the tissues, and the accumulated Kapha causes pain in many parts of the body. All the doshas go in the wrong direction, causing the body to think about its work and business and quickly take ownership of life. In this, raktavaha srotas are damaged, and the symptoms of the disease appear.
HERBAL REMEDIES FOR HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS BY PLANET AYURVEDA
Planet Ayurveda is a GMP-certified Ayurvedic centre that figures out different medicines to forestall different medical conditions and give help to wiped-out individuals. All arrangements that are formed via Planet Ayurveda contain no additives. For the treatment of Hemophagocytic lymphohistiocytosis in adults, Planet Ayurveda gives numerous herbal remedies for hemophagocytic lymphohistiocytosis that cause no side effects.
- Kanchnaar Guggul
- Boswellia Curcumin
- Immune Booster
- Giloy Ghan Vati
- Liv Support
- Gandhak Rasayan
- Telomere Boostup
PRODUCT DESCRIPTION
1. KANCHNAAR GUGGUL
These are polyherbal tablets that are made up of Bibhitaki (Terminalia bellerica), Varun bark (Crataeva religiosa), Kanchnar bark (Bauhinia variegata), Tejapatra (Cinnamomum tamala), Guggul (Commiphora mukul), and many more. Its potency is hot and it is dry. It is helpful in the reduction of vitiated Kapha and Rakta dhatu. It has anti-inflammatory and antibacterial properties. Kanchnar regulates women’s menstrual cycles. It also lowers the sugar in the blood. Tejapatra manages high levels of cholesterol because it has anti-inflammatory and antioxidant properties.
Dosage: 1-2 tablets, two or three times a day.
2. BOSWELLIA CURCUMIN
This formulation is made up of two herbs: Haridra (Curcuma longa) and Shallaki (Boswellia serrata). Its taste is bitter, and its potency is hot. It protects the brain and its functions because of its antioxidant properties. It has anti-inflammatory properties that assist in stopping the discharge of cytokines and decreasing swelling or inflammation. It is useful in immune system diseases and is compelling in malignant growth or cancer. Shallaki has astringent and antiseptic properties that manage tumours, skin disorders, etc. Haridra eliminates toxins from the body and promotes wound healing.
Dosage: 1 capsule, two times a day.
3. IMMUNE BOOSTER
These are polyherbal capsules that are made up of Bhumi amla (Phyllanthus niruri), Amalaki (Emblica officinalis), Go-Piyush (Bovine colostrums), etc. Bhumi amla is very useful in managing disorders of the liver. It has antiviral and antioxidant properties. Amalaki is useful because it improves the functioning of the brain, liver, etc. It boosts the immune system and improves your overall health.
Dosage: 1-2 capsules, two times a day.
4. GILOY GHAN VATI
It is a single herbal remedy that contains Giloy (Emblica officinalis). Its taste is astringent and bitter. Giloy improves your immunity and also protects you from various infections. It improves digestion and boosts liver function. It has anti-ageing and anti-inflammatory properties, and it also reduces anxiety and stress. This herb acts as a detoxifier. It is an amazing herb that is effective against respiratory infections. Giloy also helps to improve your eyesight. It can also be used for general fever.
Dosage: 2 tablets, two times a day.
5. LIV SUPPORT
These are polyherbal capsules that are made up of Kasani (Cichorium intybus), Bhringraj (Eclipta alba), Kalmegh (Andrographis paniculata), etc. It promotes a healthy Liver. Kasani is a very beneficial herb used as a liver tonic to treat liver diseases such as liver enlargement, fatty liver, and jaundice. The main centre of metabolism is the liver, where Kasani aids digestion by working on digestive fire due to its ushna (heat) properties. Kalmegh is often used to treat liver disease as it has antioxidant and anti-inflammatory properties that protect the liver from free radical damage. The juice of Bhringraj leaves is used as a liver tonic.
Dosage: 1 capsule, two times a day.
6. GANDHAK RASAYAN
Gandhak Rasayan is a herbal medicine that contains a single herb; Shuddh Gandhak (Purified sulphur). Gandhak is a rejuvenator that promotes immunity and health. It helps in the detoxification of the body. Gandhak Rasayan is known to improve immunity, fertility, and strength; improve stamina, strength, and nutrition; aid digestion; and improve fertility in men and women. It has antipyretic, antiviral, antibacterial, and anti-inflammatory actions.
Dosage: 1-2 tablets, two or three times a day.
7. TELOMERE BOOSTUP
These are polyherbal capsules that are made up of Moringa (Commiphora wightii), Ashwagandha (Withania somnifera), grape seed (Vitis vinifera), etc. Ashwagandha is useful to treat anxiety, stress, nervous breakdown, fatigue, weight loss, etc. Moringa has analgesic, antioxidant, diuretic, and anti-inflammatory properties. Extract grape seeds to protect against Staphylococcus aureus (a bacterial infection). Standardised extracts of grape seed might be utilised to treat a scope of medical issues connected with free radical damage, including cardiovascular diseases, cancer, and diabetes.
Dosage: 2 capsules, twice a day.
CONCLUSION
Hemophagocytic lymphohistiocytosis is a rare disease seen in infants and adults. Most children will have this problem. In adults, many things can cause hemophagocytic lymphohistiocytosis, including cancer. Adult hemophagocytic lymphohistiocytosis is a life-threatening or rare disease in immunocompromised adults. In Ayurveda, we can associate this disease with three doshas: Vata, Kapha, and Pitta. All three doshas are interrelated. All the doshas are going in the wrong direction, causing disturbances in different parts or organs of the body. There are some herbs formulated by Ayurvedic experts for the treatment of Hemophagocytic Lymphohistiocytosis, and these formulas give good results.
Dr. Vikram Chauhan
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